The purpose of ISPD Position Statements is to help facilitate the implementation of prenatal diagnostic and therapeutic policies in countries all around the world. The available multidisciplinary and international expertise within the ISPD provides the possibility to present evidence-based views from different subdisciplines and geographical backgrounds on specific prenatal diagnostic and therapeutic topics. These views are discussed extensively and consensus has to be reached bearing in mind its global applicability. It is our goal that the resulting document can be of help to those who are tasked with defining local or national policies and protocols in their countries or geographic regions. These will have to be developed and adapted with consideration of local ethics, laws, budgets and traditions of those countries and regions. ISPD Position Statements are balanced and are intended to restrain the too early and to stimulate the slow adapters.